Melanotan II (MT-II) – 10mg

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that functions as a non-selective agonist at melanocortin receptor subtypes MC1R through MC5R. This lactam-bridged peptide, with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, was originally developed as a research tool for investigating melanocortin receptor pharmacology and the diverse physiological processes regulated by the melanocortin system across various tissue types and cell lineages.

In laboratory studies, MT-2 has been employed to study melanogenesis in melanocyte cell cultures, examining the intracellular signaling cascade from MC1R activation through adenylyl cyclase stimulation, cAMP elevation, PKA activation, CREB phosphorylation, and ultimately MITF-dependent transcription of melanogenic enzymes including tyrosinase, TRP-1, and TRP-2. Beyond melanocyte biology, MT-2 serves as a valuable tool for researchers investigating the broader melanocortin system, including its roles in energy homeostasis signaling, cardiovascular regulation pathways, and neuroendocrine function in hypothalamic cell models. The non-selective receptor profile makes MT-2 particularly useful for comparative subtype contribution studies.

This compound is strictly distributed as a research chemical for scientific investigation. It is not intended for human use, cosmetic application, or any non-research purpose.